Mechanisms of genomic instability in human cancer: insights from studies with human papillomavirus oncoproteins.
نویسندگان
چکیده
Genomic instability is a hallmark of most human cancers including high-risk human papillomavirus (HPV)-associated anogenital neoplasia. The two HPV-encoded oncoproteins, E6 and E7, can independently induce chromosomal abnormalities. We summarize the current state of knowledge concerning HPV-induced genomic instability and discuss its significance in the context of human carcinogenesis.
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عنوان ژورنال:
- International journal of cancer
دوره 109 2 شماره
صفحات -
تاریخ انتشار 2004